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The use of massively parallel sequencing to study the virome, epigenome and genome of canine and feline cancers
(University of Missouri--Columbia, 2019)
The remarkable advancements in sequencing technologies have allowed the entire mutational landscape of hundreds of different types of human cancers to be defined. This knowledge gives patients two new categories of treatment ...
Viral RNA structural equilibria and their interactions with host proteins
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Understanding viral RNA structure and how it functions is crucial in elucidating new drug targets. There are many kinds of viruses that utilize RNA as a critical component...
Impact of selective motor neuron death on hypoglossal motor neuron survival and tongue morphology in a novel model of dysphagia
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Amyotrophic lateral sclerosis (ALS) is a devastating disease characterized by the progressive loss of motor neurons and paralysis of the muscles they innervate. Hypoglossal...
Tales of an 'invisible' life stage : survival and physiology among terrestrial juvenile ambystomatid salamanders
(University of Missouri--Columbia, 2019)
of the many amphibian species for which stage-specific data are lacking. Next, I reared larvae of five species (A. annulatum, A. maculatum, A. opacum, A. talpoideum, and A. texanum) from populations along an ~200 km latitudinal gradient in Missouri, USA...
Mechanisms of polar growth in the alphaproteobacterial order rhizobiales
(University of Missouri--Columbia, 2019)
All bacteria elongate and divide to faithfully reproduce their cell shape. Understanding the mechanisms that drive bacterial morphology requires an intimate knowledge of how the cell wall is synthesized. During cell ...